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Ching-Feng Weng, Professor 翁慶豐

Ching-Feng Weng, Professor, PhD

Birth date: 1954, 07, 08

Education:

University of Maryland at Baltimore, USA, PhD in Medical physiology, 1994

National Chung-Hsing Univ., Department Animal Science, MSc, Animal Nutrition 1984

National Chung-Hsing Univ., Department Animal Husbandry and Veterinary, BS 1978

E-Mail: cfweng@gms.ndhu.edu.tw

Tel: 886-3-8903637; Fax: 886-3-8630255

Research Interests:

1. Chinese medicine and herbs

2. Molecular physiology

3. Chronic disease (diabetes, liver fibrosis)

Experiences

1978-1981 Veterinary doctor, Taiwan Sugar Company, Taiwan

1981-1985 Assistant Researcher, Taiwan Pig research Institute, Taiwan

1983-1985 Adjutant Editor, China Animal science Society, Taiwan

1985-1988 Research Associate, Institute of Zoology, Academia Sinica, Taiwan

1992-1994 Assistant Researcher, Department of Pathology, Waltereed Army Hospital, USA

1994-1998 Post-doctor Fellow, Institute of. Zoology, Academia Sinica, Taiwan

1998-1998 Associate Researcher and Production Chief, National Laboratory Animal Center, Taiwan

1998-2000 Post-doctor Fellow, Institute of Zoology, Academia Sinica, Taiwan

2000-2003 Assistant Professor, Department of Life Science and Graduate Inst Biotechnology, National Dong-Hwa University

2003-2007 Associate Professor, Department of Life Science and Graduate Inst Biotechnology, National Dong-Hwa University

2007-present Professor, Department of Life Science and Graduate Inst Biotechnology, National Dong-Hwa University

2009- 2013 Chairman, Department of Life Science and Graduate Inst Biotechnology, National Dong-Hwa University

SCI Journals (2012.8.1~2018.9.30)

A. Cancer drug formulation discovery

  1. Shian-Ren Lin, Ching-Feng Weng. PG-priming enhances doxorubicin influx to trigger necrotic and autophagic cell death in oral squamous cell carcinoma J Clin Med. 2018 (in press)
  2. Chiu WJ, Lin SR, Chen YH, Tsai MJ, Leong MK, Weng CF. Prodigiosin-Emerged PI3K/Beclin-1-Independent Pathway Elicits Autophagic Cell Death in Doxorubicin-Sensitive and -Resistant Lung Cancer. J Clin Med. 2018;7(10). pii: E321.
  3. Bharath Kumar Velmurugan, Po-Chih Wang, Ching-Feng Weng 16-Hydroxycleroda-3, 13-dien-15, 16-olide and N-methyl-actinodaphine potentiates tamoxifen-induced cell death in breast cancer. Molecules 23(8) 2018; 23(8). pii: E1966.
  4. Chen C, Lee MH, Weng CF, Leong MK; Theoretical Prediction of the Complex P-Glycoprotein Substrate Efflux Based on the Novel Hierarchical Support Vector Regression Scheme. Molecules 23(7), 2018 pii: E1820. doi: 10.3390/molecules23071820
  5. Hou TY, Weng CF, Leong MK; Insight Analysis of Promiscuous Estrogen Receptor Alpha–Ligand Binding by a Novel Machine Learning Scheme. Chem. Res. Toxicol. 2018 doi: 10.1021/acs.chemrestox.8b00130.
  6. Thiyagarajan V, Lee KW, Leong MK, Weng CF; Potential natural mTOR inhibitors screened by in silico approach and suppress hepatic stellate cells activation. J. Biomol. Struct. Dyn. 2017, 1-15.
  7. Cheng MF, Lin CS, Chen YH, Sung PJ, Lin SR, Tong YW, Weng CF; Inhibitory Growth of Oral Squamous Cell Carcinoma Cancer via Bacterial Prodigiosin; Mar. Drugs 15(7), 2017, 224.
  8. Cheng MF, Lin SR, Tseng FJ, Huang YC, Tsai MJ, Fu YS, Weng CF; The autophagic inhibition oral squamous cell carcinoma cancer growth of 16-hydroxycleroda-3,13-dien-15,16-olide; Oncotarget 8(45), 2017, 78379-7896.
  9. Lin SR, Fu YS, Tsai MJ, Cheng H, Weng CF; Natural Compounds from Herbs that can Potentially Execute as Autophagy Inducers for Cancer Therapy; Int. J. Mol. Sci. 18(7), 2017, pii: E1412.
  10. Kalai Selvi S., Vinoth A., Varadharajan T., Weng CF, Vijaya Padma V.; Neferine augments therapeutic efficacy of cisplatin through ROS- mediated non-canonical autophagy in human lung adenocarcinoma (A549 cells); Food Chem Toxicol. 103, 2017, 28-40.
  11. Sivalingam KS, Paramasivan P, Weng CF, Vijaya Padma V; Neferine Potentiates the Antitumor Effect of Cisplatin in Human Lung Adenocarcinoma Cells via a Mitochondria-mediated Apoptosis Pathway. J Cell Biochem. 118(9), 2017, 2865-2876.
  12. Velmurugan, BK, Yang, HH, Sung, PJ, Weng CF; Excavatolide B inhibits nonsmall cell lung cancer proliferation by altering peroxisome proliferator activated receptor gamma expression and PTEN/AKT/NF-Kβ expression; Environ. Toxicol. 32(1), 2017, 290-301.
  13. Ma YD, Thiyagarajan V, Tsai MJ, Lue SI, Chia YC, Shyue SK, Weng CF; Pyrogallol abates VSMC migration via modulation of Caveolin-1, matrix metalloproteinase and intima hyperplasia in carotid ligation mouse; Environ Toxicol Pharmacol. 48, 2016, 63-75.
  14. Thiyagarajan V, Sivalingam KS, Viswanadha VP, Weng CF; 16-hydroxycleroda-3,13-dien-16,15-olide induced glioma cell autophagy via ROS generation and activation of p38 MAPK and ERK-1/2; Environ. Toxicol. Pharmacol; 45, 2016, 202-211.
  15. Thiyagarajan, V., Lin, SH, Chang, YC, Weng CF; Identification of novel FAK and S6K1 dual inhibitors from natural compounds via ADMET screening and molecular docking; Biomed. Pharmaco. 80, 2016, 52-62.
  16. Thiyagarajan, V., Lin, SX, Lee, CH, Weng CF; A focal adhesion kinase inhibitor 16-hydroxy-cleroda-3,13-dien-16,15-olide incorporated into enteric-coated nanoparticles for controlled anti-glioma drug delivery; Colloids Surf B Biointerfaces. 141, 2016, 120-131.
  17. Chen ZA, Kuthati Y, Kankala RK, Chang YC, Liu CL, Weng CF, Mou CY, Lee CH; Encapsulation of palladium porphyrin photosensitizer in layered metal oxide nanoparticles for photodynamic therapy against skin melanoma; Sci. Technol. Adv. Mater. 16(5), 2015, 054205.
  18. Thiyagarajan, V., Tsai, M. J., Weng CF; Antroquinonol Targets FAK-Signaling Pathway Suppressed Cell Migration, Invasion, and Tumor Growth of C6 Glioma. PLoS One; 10(10), 2015, e0141285.
  19. Poornima P, Kumar VB, Weng CF, Padma VV; Doxorubicin induced apoptosis was potentiated by neferine in human lung adenocarcima A549 cells; Food Chem. Toxicol. 68, 2014, 87-98.
  20. Poornima P, Weng CF, Padma VV; Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest; Biofactors. 40(1), 2014, 121-31.
  21. Poornima P, Weng CF, Padma VV; Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells; Food Chem. 141(4), 2013, 3598-605.
  22. Kuthati Y, Sung PJ, Weng CF, Mou CY, Lee CH; Functionalization of mesoporous silica nanoparticles for targeting, biocompatibility, combined cancer therapies and theragnosis. J. Nanosci. Nanotechnol. 13(4), 2013, 2399-2430.
  23. Thiyagarajan V, Lin SH, Chia YC, Weng CF; A novel inhibitor, 16-hydroxycleroda-3,13-dien-16,15-olide, blocks the autophosphorylation site of focal adhesion kinase (Y397) by molecular docking; Biochim. Biophys. Acta. 1830(8), 2013, 4091-4101.
  24. Lin CH, Cheng SH, Liao WN, Wei PR, Sung PJ, Weng CF, Lee CH; Mesoporous silica nanoparticles for the improved anticancer efficacy of cis-platin; Int. J. Pharm. 429(1-2), 2012, 138-147.

B. Hypoglycemic drug formulation and natural hypoglycemic drug screening.

 

  1. Huang PK, Lin SR, Chang CH, Tsai MJ, Lee DN, Weng CF; Natural phenolic compounds potentiate hypoglycemia via inhibition of Dipeptidyl peptidase IV; Sci. Rep.; 2018, (In press).
  2. Hou TY, Weng CF, Leong MK. Insight Analysis of Promiscuous Estrogen Receptor α-Ligand Binding by a Novel Machine Learning Scheme. Chem Res Toxicol. 2018; 31(8):799-813.
  3. Chen C, Lee MH, Weng CF, Leong MK. Theoretical Prediction of the Complex P-Glycoprotein Substrate Efflux Based on the Novel Hierarchical Support Vector Regression Scheme. Molecules. 2018; 23(7). pii: E1820.
  4. Velmurugan BK, Rathinasamy B, Lohanathan BP, Thiyagarajan V, Weng CF. Neuroprotective Role of Phytochemicals. Molecules. 2018; 23(10). pii: E2485. Review.
  5. Riyaphan J, Jhong CH, Lin SR, Chang CH, Tsai MJ, Lee DN, Sung PJ, Leong MK, Weng CF. Hypoglycemic Efficacy of Docking Selected Natural Compounds against α-Glucosidase and α-Amylase. Molecules. 2018; 23(9). pii: E2260.
  6. Huang PK, Lin SX, Tsai MJ, Leong MK, Lin SR, Kankala RK, Lee CH, Weng CF; Encapsulation of 16-Hydroxycleroda-3,13-dien-16,15-Olide in Mesoporous Silica Nanoparticles as a Natural Dipeptidyl Peptidase-4 Inhibitor Potentiated Hypoglycemia in Diabetic Mice; Nanomaterials,7(5), 2017, 112.
  7. Jhong, CH, Riyaphan, J, Lin, SH, Chia, YC, Weng CF; Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico; Biofactors. 41(4), 2015, 242-251.
  8. Sulake, RS, Lin, HH, Hsu, CY, Weng CF, Chen, C.; Synthesis of (+)-Antroquinonol: An Antihyperglycemic Agent; J. Org. Chem. 80(12), 2015, 6044-6051.
  9. Hsu CY, Shih HY, Chang YC, Huang ZL, Tsai MJ, Chia YC, Chen C, Lai YK, Weng CF; The beneficial effects of tetracosanol on insulin-resistance by insulin receptor kinase sensibilization; J. Funct. Foods; 14, 2015, 174-182.
  10. Hsu CY, Sulake RS, Huang PK, Shih HY, Sie HW, Lai YK, Chen C, Weng CF; Synthetic of (+)-antroquinonol possesses dual efficacy for insulin-resistance via triggering AMPK and anti- DPP IV activity; Br. J. Pharmacol. 172(1), 2015, 38-49.
  11. Hsu CY, Shih HY, Chia YC, Lee CH, Ashida H, Lai YK, Weng CF; Rutin potentiates insulin receptor kinase to enhance insulin-dependent glucose transporter 4 translocation; Mol. Nutr. Food Res. 58(6), 2014, 1168-76.
  12. Lin YC, Chen LH, Varadharajan T, Tsai MJ, Chia YC, Yuan TC, Sung PJ, Weng CF; Resveratrol inhibits glucose-induced migration of vascular smooth muscle cells mediated by focal adhesion kinase; Mol. Nutr. Food Res. 58(7), 2014, 1389-1401.

C. Cancer biology

  1. Chen LH, Hsu WL, Tseng YJ, Liu DW, Weng CF; Involvement of DNMT 3B promotes epithelial-mesenchymal transition and gene expression profile of invasive head and neck squamous cell carcinomas cell lines; BMC Cancer; 16, 2016, 431.
  2. Wang KH, Lin CJ, Liu CJ, Liu DW, Huang RL, Ding DC, Weng CF, Chu TY; Global methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV; Cancer Med. 4(1), 2015, 43-55.
  3. Chen LH, Liu DW, Chang JL, Chen PR, Hsu LP, Lin HY, Chou YF, Lee CF, Yang MC, Wen YH, Hsu WL, Weng CF; Methylation status of insulin-like growth factor-binding protein 7 concurs with the malignance of oral tongue cancer. J. Exp. Clin. Cancer Res. 34, 2015, 20.
  4. Wang KH, Lin CJ, Liu CJ, Liu DW, Huang RL, Ding DC, Weng CF, Chu TY; Global methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV; Cancer Med. 4(1), 2015, 43-55.
  5. Wu TF, Luo FJ, Chang YL, Huang CM, Chiu WJ, Weng CF, Hsu YK, Yuan TC; The oncogenic role of androgen receptors in promoting the growth of oral squamous cell carcinoma cells. Oral Dis.; 21(3), 2015, 320-327.

D. Treatment for cardiovascular disease and others

  1. Kankala RK, Kuthati Y, Sie HW, Shih HY, Lue SI, Kankala S, Jeng CC, Deng JP, Weng CF, Liu, CL, Lee CH; Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice; J. Colloid Interface Sci. 458, 2015, 217-228.
  2. Lin SH, Huang KJ, Weng CF, Shiuan D; Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening. Drug Des. Devel. Ther. 9, 2015, 3313-3324.
  3. Tseng FJ, Chia WT, Wang CH, Shyu JF, Gou GH, Shui HA, Sytwu HK, Pan RY, Weng CF; Carbon Monoxide Inhibits Receptor Activator of NF-kappaB (RANKL)-Induced Osteoclastogenesis; Cell Physiol. Biochem. 36(3), 2015, 1250-1258.
  4. Lee KW, Thiyagarajan V, Sie HW, Cheng MF, Tsai MJ, Chia YC, Weng CF; Synergistic effect of natural compounds on the fatty acid-induced autophagy of activated hepatic stellate cells; J. Nutr. Biochem. 2014, pii: S0955-2863(14)00082-5.
  5. Chen YR, Chang KT, Tsai MJ, Lee CH, Huang KJ, Cheng H, Ho YP, Chen JC, Yang HH, Weng CF; Antrodia cinnamomea profoundly exalted the reversion of activated hepatic stellate cells by the alteration of cellular proteins; Food Chem. Toxicol. 69, 2014, 150-62.
  6. Hsu YJ, Weng CF, Lin KW, Lin KC; Suppression of allergic reactions in ovalbumin-sensitized mice by yam storage proteins dioscorins; J. Agric. Food Chem. 61(47), 2013, 11460-11467.

E. Formulations for anti-bacteria

  1. Kuthati Y, Kankala RK, Lin SX, Weng CF, Lee CH; pH-Triggered Controllable Release of Silver-Indole-3 Acetic Acid Complexes from Mesoporous Silica Nanoparticles (IBN-4) for Effectively Killing Malignant Bacteria; Mol. Pharm. 12(7), 2015, 2289-2304.
  2. Chen YH, Kuo J, Sung PJ, Chang YC, Lu MC, Wong TY, Liu JK, Weng CF, Twan WH, Kuo FW; Isolation of marine bacteria with antimicrobial activities from cultured and field-collected soft corals; World J. Microbiol. Biotechnol. 28(12), 2012, 3269-3279.

F. Tilapia and bufo physiology

  1. Yu TL, Lin HD, Weng CF; A new phylogeographic pattern of endemic Bufo bankorensis in Taiwan Island is attributed to the genetic variation of populations; PLoS One; 9(5), 2014, e98029.
  2. Tang ZJ, Lue SI, Tsai MJ, Yu TL, Thiyagarajan V, Lee CH, Huang WT, Weng CF; The hormonal regulation of color changes in the sexually dichromatic frog Buergeria robusta; Physiol. Biochem. Zool. 87(3), 2014, 397-410.
  3. Chen CC, Li KW, Yu TL, Chen LH, Sheu PY, Tong YW, Huang KJ, Weng CF; Genetic structure of Bufo bankorensis distinguished by amplified restriction fragment length polymorphism of cytochrome b; Zoological Studies; 52, 2013, 48-57.

G. Marine compounds

  1. Velmurugan BK, Yang HH, Sung PJ, Weng CF; Excavatolide B inhibits nonsmall cell lung cancer proliferation by altering peroxisome proliferator activated receptor gamma expression and PTEN/AKT/NF‐Kβ expression. Environ. Toxicol., 32(1), 2017, 290-301.
  2. Chen YH, Chen WF, Yang JC, Lu MC, Kuo J, Su JH, Weng CF, Wu YC, Sung PJ; Pseudoalteromone C: a novel ubichromenol derivative from bacterium Pseudoalteromonas sp. CGH2XX isolated from the cultured-type octocoral Lobophytum crissum; Nat. Prod. Commun. 12(0), 2017, 1-2.
  3. Chen YH, Yang JC, Lu MC, Weng CF, Su YD, Kuo J, Wu YC, Sung PJ; Bafilomycins N and O, novel cytotoxic bafilomycin analogues produced by Streptomyces sp. GIC10-1 isolated from marine sponge Theonella sp. Tetrahedron; 73(34), 2017, 5170-5175.
  4. Chen YH, Lu MC, Chung HM, Weng CF, Su JH, Yang YT, Su YD, Chang YC, Kuo J, Wu YC, Sung PJ; Bafilomycin M, a new cytotoxic bafilomycin produced by a Streptomyces sp. isolated from a marine sponge Theonella sp. Tetrahedron Lett.; 57(43), 2016, 4863-4865.
  5. Sheu JH, Chen YH, Chen YH, Su YD, Chang YC, Su JH, Weng CF, Lee CH, Fang LS, Wang WH, Wen ZH, Wu YC, Sung PJ; Briarane diterpenoids isolated from gorgonian corals between 2011 and 2013; Mar. Drugs; 12(4), 2014, 2164-81.
  6. Lin CY, Lu MC, Su JH, Chu CL, Shiuan D, Weng CF, Sung PJ, Huang KJ; Immunomodulatory effect of marine cembrane-type diterpenoids on dendritic cells. Mar. Drugs; 11(4), 2013, 1336-50.
  7. Yen WH, Hu LC, Su JH, Lu MC, Twan WH, Yang SY, Kuo YC, Weng CF, Lee CH, Kuo YH, Sung PJ. Norcembranoidal diterpenes from a Formosan soft coral Sinularia sp.; Molecules; 17(12), 2012, 14058-14066.
  8. Chen YH, Lu MC, Chang YC, Hwang TL, Wang WH, Weng CF, Kuo J, Sung PJ; Pseudoalteromone A: A novel bioactive ubiquinone from a marine bacterium Pseudoalteromonas sp. CGH2XX (Pseudoalteromonadaceae); Tetrahedron Lett.; 53(13), 2012, 1675-1677.
  9. Chen YH, Kuo J, Su JH, Hwang TL, Chen YH, Lee CH, Weng CF, Sung PJ; Pseudoalteromone B: a novel 15C compound from a marine bacterium Pseudoalteromonas sp. CGH2XX; Mar. Drugs; 10(7), 2012, 1566-71.
  10. Hong PH, Su YD, Su JH, Chen YH, Hwang TL, Weng CF, Lee CH, Wen ZH, Sheu JH, Lin NC, Kuo YH, Sung PJ; Briarenolides F and G, new briarane diterpenoids from a Briareum sp. octocoral; Mar. Drugs; 10(5), 2012, 1156-1168.
  11. Chen YH, Kuo J, Sung PJ, Chang YC, Lu MC, Wong TY, Liu JK, Weng CF, Twan WH, Kuo FW; Isolation of marine bacteria with antimicrobial activities from cultured and field-collected soft corals. World J. Microbiol. Biotechnol.; 28, 2012, 3269–3279.

H. Others

  1. Chen SF, Chao YL, Shen YC, Chen CH, Weng CF; Resequencing and association study of the NFKB activating protein-like gene (NKAPL) in schizophrenia; Schizophr. Res.; 2014, pii: S0920-9964(14)00294-1.
  2. Tsai MJ, Weng CF, Yu NC, Liou DY, Kuo FS, Huang MC, Huang WC, Tam K, Shyue SK, Cheng H; Enhanced prostacyclin synthesis by adenoviral gene transfer reduced glial activation and ameliorated dopaminergic dysfunction in hemiparkinsonian rats. Oxid. Med. Cell Longev.; 2013, 2013, 649809.
  3. Wei PR, Cheng SH, Liao WN, Kao KC, Weng CF, Lee CH; Synthesis of chitosan-coated near-infrared layered double hydroxide nanoparticles for in vivo optical imaging; J. Mater. Chem.; 22, 2012, 5503-5513.

Patents

1.     張春生, 李松泰, 翁慶豐; 使用經由粉擬青黴菌G30801的培育而得到的產物來治療第一型或第二型糖尿病; TW Patent I376229; Nov, 2011.

2.     吳茂昆, 翁慶豐, 史閎元, 謝蕙雯; 含綬草萃取物的組合物及其醫藥應用; TW Patent I578991; Apr, 2017.

3.     翁慶豐, 賈宜琛, 邱韋鈞; 治療肺癌的方法及醫藥組合物; TW Patent I547279; Sep, 2016.

4.     翁慶豐, 賈宜琛, 吳嘉仁, 蔡湘儀; 用以預防及/或治療肝纖維化的方法及醫藥組合物; TW Patent I515002; Jan, 2016.

5.     翁慶豐, 李佳洪, 賈宜琛用於癌症治療之16-羥基克羅烷-3,13-二烯-15,16-內酯製劑; TW Patent 201630594; Sep, 2016.

6.     Weng; Ching-Feng, Chia; Yi-Chen, Lee; Chia-Hung, Varadharajan; T.; HCD formulation for cancer treatment. US. Patent 9.682.003 A; Aug 25, 2016.

7.     Weng; Ching-Feng, Chen; Chin-piao, Shivaji; Sulake Rohidas, Hsu; Chia-Yu; Compounds from Antrodia camphorate and their use in treatment of diabetes mellitus. US Patent 9.604.894; Jul 23, 2015.

8.     Weng; Ching-Feng, Chen; Chin-piao, Chia; Yi-Chen, Hsu; Chia-Yu; Method and composition for treating diabetes mellitus. US Patent 9.226.950; May 14, 2015.

9.     WU; Maw-Kuen; Weng, Ching-Feng; Shih, Hung-Yuan; Sie, Huei-Wun; Composition containing a spiranthes sinensis extract and pharmaceutical applications thereof. US Patent US20150250843A1; Sep, 10, 2015.

 

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